Reduced S-acylation of SQSTM1p62 in Huntington disease is

p62 com  The p62 protein, also called sequestosome 1 , is a ubiquitin-binding scaffold protein that colocalizes with ubiquitinated protein aggregates in many This review discusses new knowledge in p62 biology with a focus on the role of p62 during cellular stress and aging, and in age-related diseases

Expression of p62 is required for efficient autophagy of bacteria, as well as restriction of their intracellular replication Our studies demonstrate that the Here we show that the human cargo receptor p62SQSTM-1 employs oligomerization to stabilize its interaction with LC3B and linear ubiquitin when

p62SQSTM1 is a multifunctional scaffold protein which forms oligomers with itself or with other proteins through interactions with PB1 domains Abnormal Synopsis image p62 and ubiquitinated substrates spontaneously coalesce into larger clusters, which result from the crosslinking of p62 filaments by the